The RAD51 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to RAD51 recombinase (RAD51). This antibody recognizes Homo Sapiens, and Human antigen. The RAD51 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Immunohistochemistry.
Description
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange(PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3